Madikwe Safari Lodge is situated in the heart of the richly diverse and malaria-free 76 000-hectare (187 800-acre) Madikwe Game Reserve - one of South Africa's biggest wildlife sanctuaries. Famed for Operation Phoenix, the world's largest game translocation exercise with the introduction of more than 8 000 animals, Madikwe's diverse geology and broad mix of habitats allows a wide range of African wildlife to flourish - including the Big Five, cheetah and a thriving population of wild dog.

Set on a gentle slope nestled between two rolling hills, Madikwe Safari Lodge overlooks game-filled plains with the Dwarsberg Hills in the distance and the Marico River nearby. The region is also imbued in history and has seen the passage of Mzilikazi and a range of explorers, traders, hunters and missionaries, including Dr David Livingstone, Sir Cornwallis Harris and the famous South African author, Herman Charles Bosman. In line with Conservation Corporation Africa's (CC Africa) vision, Madikwe Game Reserve is run as a joint venture between the North West Parks Board, the private sector and the local communities.